To Our Stockholders, Employees and Friends: Since the founding of our company in 1987, Gilead has focused on developing and delivering medications that advance the treatment of life-threatening diseases worldwide. This is our singular motivation – it is why we are here. Our achievements in 2006 are the result of progress that can be traced over many years and, at the same time, create a foundation for continued growth in 2007 and beyond.

MARKET LEADERSHIP IN HIV, HEPATITIS B AND INFLUENZA

The year 2006 marked the 25th anniversary of the first reported AIDS cases in the United States. Over the course of the last five years, Gilead has contributed to the tremendous progress made in the treatment of HIV/AIDS. Today, our HIV therapies are critical components of the most-prescribed highly active antiretroviral therapy (HAART) regimens and have contributed to the overall success of this treatment paradigm by helping to greatly reduce pill burden. Backed by years of safety and efficacy data, Viread and Truvada have each carved out leadership positions among HIV treatments. As the first and only complete HAART combination in a once-daily single tablet, Atripla has quickly joined their ranks since its U.S. approval in July 2006. Our HIV franchise, which consists of Viread, Emtriva, Truvada and Atripla, generated more than
$2 billion in product sales in 2006.

In 2006, Gilead’s products and partnerships generated more than $3 billion in total revenues. Now in our 20th year, we are pleased with the rapid growth and continued commercial success of our products. And, most importantly, we are proud that through our efforts to deliver innovative therapeutics, we are improving the lives of patients who are suffering from life-threatening diseases.

Infectious diseases, in particular, have been the focus of our efforts and the foundation of our business for nearly two decades. This year we leveraged our strong financial position to broaden our product portfolio beyond infectious diseases and position the company for long-term growth. Our acquisitions of Corus Pharma, Inc. and Myogen, Inc., and their investigational and commercial products, will be the cornerstone of our new respiratory and cardiopulmonary portfolio – expanding our ability to fulfill our strategic objective of developing and commercializing novel products that deliver therapeutic advancements to physicians and patients around the world.

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