Pipeline
Last Updated Date: December 22, 2022
The impossible is simply what hasn’t been achieved yet. Gilead’s research and development program is focused on what’s next. We discover, identify and evaluate investigational compounds that show potential to advance the treatment of life-threatening diseases.
Clinical Stage Programs1
Potential clinical stage opt-in assets
1 Program count does not include potential partner opt-in programs or publicly announced planned programs.
On this page
Viral Diseases
Inflammatory Diseases

The safety and efficacy of the following investigational compounds or investigational uses of marketed products have not been established. These uses have not been approved by the U.S. Food and Drug Administration or other regulatory authorities unless otherwise noted.
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Novel oral COVID-19 nucleoside (GS-5245)
COVID-19
PHASE 1
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Lenacapavir (PURPOSE 1 & 2)
HIV PrEP
PHASE 3
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Lenacapavir / bictegravir oral combination (ARTISTRY-1)
Long acting HIV treatment for virologically suppressed people living with HIV
PHASE 2/3
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Lenacapavir1
Long acting HIV treatment for virologically suppressed people living with HIV
PHASE 2
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Lenacapavir/islatravir oral combination3
Long acting HIV treatment for virologically suppressed people living with HIV
PHASE 2
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bNAb combination (GS-5423, GS-2872)4
HIV cure
PHASE 2
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Lefitolimod4
HIV cure
PHASE 2
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Vesatolimod4
HIV cure
PHASE 2
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Therapeutic vaccines5
HIV cure
PHASE 1
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Lenacapavir / bNAb combination
Long acting HIV treatment for virologically suppressed people living with HIV
PHASE 1
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Long acting INSTI (GS-6212)
Long acting HIV treatment
PHASE 1
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HIV NNRTI (GS-5894)
Long acting HIV treatment
PHASE 1
HBV and HDV
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Hepcludex® (MYR301)6,7
HDV
FILED BLA
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Bulevirtide (MYR301, MYR204)
HDV Finite Treatment
PHASE 3
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Selgantolimod
HBV cure
PHASE 2
1 Breakthrough therapy designation.
2 Phase 2 study being conducted in treatment naïve patients to support virologically suppressed indication.
3 Subject to Gilead and Merck co-development and co-commercialization agreement.
4 Non-Gilead sponsored trial(s) ongoing.
5 Clinical collaboration with Gritstone
6 Conditionally approved by the European Medicines Agency (EMA) for the treatment of chronic HDV infection in adults with compensated liver disease in July 2020.
7 Breakthrough and PRIME designations.
bNAb – Broadly neutralizing antibody
CoV – Coronavirus
HBV – Hepatitis B virus
HDV – Hepatitis delta virus
HIV – Human immunodeficiency virus
INSTI – Integrase strand transfer inhibitor
NNRTI – Non-nucleoside reverse transcriptase inhibitor
PrEP – Pre-exposure prophylaxis
Inflammatory Diseases
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TPL2 inhibitor (GS-5290)
Inflammatory bowel disease
PHASE 1
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IRAK4 inhibitor (GS-5718)
Inflammatory bowel disease
PHASE 1
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IRAK4 inhibitor (GS-5718)
Rheumatoid arthritis
PHASE 1
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IRAK4 inhibitor (GS-5718)1
Lupus
PHASE 1
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α4β7 inhibitor (GS-1427)
Inflammatory bowel disease
PHASE 1
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BTLA agonist (GS-0272)
Inflammatory diseases
PHASE 1
Fibrotic Diseases
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Cilofexor / firsocostat / semaglutide combination2
Nonalcoholic steatohepatitis
PHASE 2
Potential Opt-in Programs
Galapagos
Inflammatory and fibrotic diseases
3 clinical stage programs
1 Screening/enrollment paused pending evaluation of preliminary preclinical findings.
2 Clinical collaboration with Novo Nordisk.
BTLA – B- and T-lymphocyte attenuator
IRAK4 – Interleukin 1 receptor associated kinase 4
TPL2 – Tumor progression locus 2
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Sacituzumab govitecan-hziy (TROPiCS-02)
Hormone receptor positive, human epidermal growth factor receptor 2 negative, metastatic breast cancer
FILED sBLA
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Trodelvy® (TROPiCS-04)
2L metastatic urothelial carcinoma
PHASE 3
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Sacituzumab govitecan-hziy (EVOKE-01)
2-3L non small cell lung cancer
PHASE 3
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Sacituzumab govitecan-hziy (ASCENT-03)
1L metastatic triple-negative breast cancer (PD-L1-)
PHASE 3
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Sacituzumab govitecan-hziy + pembrolizumab (ASCENT-04)1
1L metastatic triple-negative breast cancer (PD-L1+)
PHASE 3
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Sacituzumab govitecan-hziy + pembrolizumab (EVOKE-03)1,2
1L non small cell lung cancer
PHASE 3
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Magrolimab + azacitidine (ENHANCE)3,4
1L higher risk myelodysplastic syndrome
PHASE 3
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Magrolimab + azacitidine (ENHANCE-2)4
1L TP53m acute myeloid leukemia
PHASE 3
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Magrolimab + venetoclax + azacitidine (ENHANCE-3)
1L unfit acute myeloid leukemia
PHASE 3
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Domvanalimab + zimberelimab (ARC-10)5
1L non small cell lung cancer
PHASE 3
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Domvanalimab + durvalumab (PACIFIC-8)6
Stage 3 non small cell lung cancer
PHASE 3
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Domvanalimab + zimberelimab + chemotherapy (STAR-121)2,5
1L non small cell lung cancer
PHASE 3
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Sacituzumab govitecan-hziy + pembrolizumab (EVOKE-02)1
1L non small cell lung cancer
PHASE 2
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Sacituzumab govitecan-hziy + combinations (TROPHY-U-01)
1L metastatic urothelial carcinoma
PHASE 2
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Sacituzumab govitecan-hziy (TROPiCS-03)
Basket (Solid tumors)
PHASE 2
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Magrolimab + chemotherapy/IO combinations
Head and neck squamous cell carcinoma
PHASE 2
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Magrolimab + chemotherapy
Solid tumors
PHASE 2
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Magrolimab combinations
Multiple myeloma
PHASE 2
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Magrolimab + chemotherapy/SG combinations
Triple-negative breast cancer
PHASE 2
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Magrolimab combinations
Metastatic colorectal cancer
PHASE 2
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Domvanalimab + zimberelimab + etrumadenant (ARC-7)5
Non small cell lung cancer
PHASE 2
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Quemliclustat + zimberelimab (ARC-8)5
Metastatic pancreatic ductal adenocarcinoma
PHASE 2
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Etrumadenant + zimberelimab combinations (ARC-9)5
Metastatic colorectal cancer
PHASE 2
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Domvanalimab + zimberelimab + chemotherapy (ARC-21)5
1-2L upper GI cancer
PHASE 2
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Etrumadenant + zimberelimab combinations (ARC-6)5
Metastatic castrate-resistant prostate cancer
PHASE 1b/2
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Magrolimab anti-CD47 (GS-4721)
Magrolimab combinations
PHASE 1b/2
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AB308 + zimberelimab (ARC-12)5
Advanced cancers
PHASE 1b
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Flt3R agonist (GS-3583)
Advanced cancers
PHASE 1b
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CCR8 (GS-1811)
Advanced cancers
PHASE 1a
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MCL1 inhibitor (GS-9716)
Advanced cancers
PHASE 1a
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Axicabtagene ciloleucel (ZUMA-22)
2L+ high-risk follicular lymphoma
PHASE 3
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Axicabtagene ciloleucel (ZUMA-23)2
1L high-risk large B-cell lymphoma
PHASE 3
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Axicabtagene ciloleucel (ZUMA-24)
2L large B-cell lymphoma outpatient
PHASE 2
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Axicabtagene ciloleucel (ZUMA-12)
1L large B-cell lymphoma
PHASE 2
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Brexucabtagene autoleucel (ZUMA-4)
Pediatric acute lymphocytic leukemia
PHASE 2 Pivotal
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Brexucabtagene autoleucel (ZUMA-25)2
Basket (rare B-cell malignancies)
PHASE 2
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CLL-1 (KITE-222)
Relapsed/refractory acute myeloid leukemia
PHASE 1
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CD19/20 bicistronic (KITE-363)
3L+ diffuse large B-cell lymphoma
PHASE 1
Potential Opt-in Programs
Pionyr
Advanced cancers
2 clinical stage programs
Agenus
Advanced cancers
1 clinical stage program
Arcus
Advanced cancers
1 clinical stage program
Tizona
Advanced cancers
1 clinical stage program
MacroGenics
Advanced cancers
1 clinical stage program
Galapagos
Advanced cancers
1 clinical stage program
1 In collaboration with Merck.
2 Publicly announced planned program (non-exhaustive).
3 Breakthrough and PRIME designations and Promising Innovative Medicine from MHRA.
4 Additional MDS and AML cohorts within other ongoing Phase 1b study.
5 In collaboration with Arcus Biosciences.
6 In collaboration with Arcus Biosciences and AstraZeneca.
GI – Gastrointestinal
IO – Immuno-oncology
MCL1 – myeloid cell leukemia-1
PD-L1 – Programmed death-ligand 1
SG - Sacituzumab govitecan-hziy
TP53m – Tumor protein 53 mutation
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