January 09, 2020
Gilead Sciences Licenses Portfolio of HIV Antibodies From The Rockefeller University
HIV bNAbs are a class of immunotherapy agents that were originally derived from HIV-infected individuals with a strong anti-HIV immunologic response and were designed to target HIV, particularly originating from the latent viral reservoir. Initial pre-clinical and clinical research has shown that HIV bNAbs can produce an enhanced, prolonged immune response to HIV, representing a promising new approach for HIV treatment or prevention in combination with other long-acting agents, or prolonged virologic remission in the absence of antiretroviral use. This licensing agreement provides an additional pathway for innovations in Gilead’s HIV pipeline in areas of evolving and unmet medical need.
“The Rockefeller University’s broadly neutralizing HIV antibodies are well studied and have shown exceptional promise in early clinical trials,” said
“Our scientists have amassed an extensive body of research showing that neutralizing antibodies have the potential to transform HIV therapy for many people living with the disease,” said
Under the agreement, Gilead acquires exclusive global licenses to develop and commercialize Rockefeller’s full portfolio of HIV bNAbs. Rockefeller will receive an upfront payment and is eligible to receive cumulative milestone payments, as well as royalties on net sales. Additionally, Rockefeller will retain rights to perform non-clinical and early-stage clinical research on the portfolio of HIV antibodies.
Antibodies 3BNC117 and 10-1074 are investigational therapies and are not approved by any regulatory body globally; their safety and efficacy have not been established. There is no cure for HIV or AIDS.
For more than 30 years, Gilead has been a leading innovator in the field of HIV, driving advances in treatment, prevention, testing and linkage to care, and cure research. Today, it is estimated that more than 12 million people living with HIV globally receive antiretroviral therapy provided by Gilead or one of the company’s manufacturing partners.
This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks, uncertainties and other factors, including the risk that the parties may not realize the potential benefits of this collaboration. It is possible that Gilead may make a strategic decision to discontinue development of 3BNC117, 10-1074 and other HIV bNAbs if, for example, Gilead believes commercialization will be difficult relative to other opportunities in its pipeline. As a result, these HIV bNAbs may never be successfully commercialized. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. These risks, uncertainties and other factors could cause actual results to differ materially from those referred to in the forward-looking statements. The reader is cautioned not to rely on these forward-looking statements. These and other risks are described in detail in Gilead’s Quarterly Report on Form 10-Q for the quarter ended
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Douglas Maffei, Ph.D., Investors
Ryan McKeel, Media